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The trial data were monitored by staff from the coordinating center. In an embodiment, the substituted tetracycline compounds used in the methods and compositions of the invention are substituted sancycline compounds, eg, with substitution at the, for example, 2, 5, 6, 7, 8, 9, 10, 11, 11a, 12, 12a position and/or, accutane cash price the case of methacycline, the 13 position.

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